The city can be broken down into the Downtown area, called the Golden Triangle, and four main areas surrounding it. These four surrounding areas are further subdivided into distinct neighborhoods (in total, Pittsburgh contains 90 neighborhoods.) These areas, relative to downtown, are known as the North Side, South Side/South Hills, East End, and West End.
Downtown Pittsburgh is tight and compact, featuring many skyscrapers, 9 of which top 500 feet. U.S. Steel Tower is the tallest at 841 feet. The Cultural District comprises a 14 block area of downtown along the Allegheny River. It is packed with theaters and arts venues, and is seeing a growing residential segment. Most significantly, the Pittsburgh Cultural Trust is embarking on Riverparc, a 4-block mixed-use "green" community, featuring 700 residential units and multiple towers between 20–30 stories. The Firstside portion of downtown borders the Monongahela River and the historic Mon Wharf. This area is home to the distinctive PPG Place Gothic glass skyscraper complex. This area too, is seeing a growing residential sector, as new condo towers are constructed and historic office towers are converted to residential use. Downtown is serviced by the Port Authority's light rail and multiple bridges leading north and south. It is also home to Point Park University, The Art Institute of Pittsburgh, Pittsburgh Culinary Institute, a RobertMorris University branch campus and Duquesne University which is located on the border of Downtown and Uptown.
The North Side is home to various neighborhoods in transition. The North Side is primarily composed of residential neighborhoods and is noteworthy for well-constructed and architecturally interesting homes. Many buildings date from the 19th century and are constructed of brick or stone and adorned with decorative woodwork, ceramic tile, slate roofs and stained glass. The North Side is also home to many popular attractions such as Heinz Field, PNC Park, Carnegie Science Center, National Aviary, Andy Warhol Museum, Mattress Factory installation art museum, Children's Museum of Pittsburgh, Penn Brewery and Allegheny Observatory.
The South Side was once an area composed primarily of dense inexpensive housing for mill workers, but has in recent years become a local Pittsburgher destination. In fact, South Side is one of the most popular neighborhoods to own a home in Pittsburgh. The value of homes in the South Side have increased in value by about 10 percent annually for the past 10 years. The South Side's East Carson Street is one of the most vibrant areas of the city, packed with diverse shopping, ethnic eateries, pulsing nightlife and live music venues. In 1993 the Urban Redevelopment Authority of Pittsburgh purchased the South Side Works steel mill property, and worked together with the community and various developers to create a master plan for a mixed-use development including a riverfront park, office space, housing, health-care facilities, and the Pittsburgh Steelers and Pitt Panthers indoor practice fields. Construction began in 1998, and the Southside Works is now open for business with many store, restaurants, offices, and the world headquarters for American Eagle Outfitters.
Homes along East Carson Street on the city’s South Side
The East End is home to the University of Pittsburgh, Carnegie Mellon University, CarlowUniversity, Chatham University, The Carnegie Institute's Museums of Art and Natural History, Frick Art & Historical Center (Clayton and the Frick art museum), Phipps Conservatory, Soldiers and Sailors Memorial Hall, and the Pittsburgh Zoo and PPG Aquarium. The neighborhoods of Shadyside and Squirrel Hill are large, wealthy neighborhoods featuring large shopping/business districts. Oakland, heavily populated by undergraduate and graduate students, is home to most of the universities, Schenley Park and the Petersen Events Center. Bloomfield is Pittsburgh's Little Italy and is known for its Italian restaurants and grocers. Lawrenceville is a revitalizing rowhouse neighborhood popular with artists and designers. The Strip District is a popular open-air marketplace by day and one of Pittsburgh's hottest clubbing destinations by night.
Shadyside, a neighborhood in the East Side
The West End includes Mt. Washington, with its famous view of the Downtown skyline and numerous other residential neighborhoods like Sheraden and Elliott. Pittsburgh's patchwork of neighborhoods still retain an ethnic character reflecting the city's immigrant history. This includes:
- African American: Hill District and Homewood,
- Jewish: Squirrel Hill
- Italian: Bloomfield
- German: Troy Hill and East Allegheny
- Polish and other Eastern European: South Side, Lawrenceville, and Polish Hill
Several neighborhoods on the edges of the city are less urban, featuring tree-lined streets, yards and garages giving a more characteristic suburban feel, while other aforementioned neighborhoods, such as Oakland, the South Side, the North Side, and the Golden Triangle are characterized by a more diverse, urban feel.
The South Side was once an area composed primarily of dense inexpensive housing for mill workers, but has in recent years become a local Pittsburgher destination. In fact, South Side is one of the most popular neighborhoods to own a home in 
Shadyside, a neighborhood in the East Side